{"id":17518,"date":"2026-11-05T19:34:05","date_gmt":"2026-11-05T18:34:05","guid":{"rendered":"https:\/\/womenhouse.cz\/?p=17518"},"modified":"2026-11-05T19:35:40","modified_gmt":"2026-11-05T18:35:40","slug":"nova-lecba-nadoru-mozku-muze-zmenit-prognozu-pacientu-ma-potencial-ovlivnit-rust-nadoru-a-oddalit-ozarovani-i-chemoterapii","status":"publish","type":"post","link":"https:\/\/womenhouse.cz\/index.php\/2026\/11\/05\/nova-lecba-nadoru-mozku-muze-zmenit-prognozu-pacientu-ma-potencial-ovlivnit-rust-nadoru-a-oddalit-ozarovani-i-chemoterapii\/","title":{"rendered":"Nov\u00e1 l\u00e9\u010dba n\u00e1dor\u016f mozku m\u016f\u017ee zm\u011bnit progn\u00f3zu pacient\u016f. M\u00e1 potenci\u00e1l ovlivnit r\u016fst n\u00e1doru a odd\u00e1lit oza\u0159ov\u00e1n\u00ed i chemoterapii"},"content":{"rendered":"\n
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Celosv\u011btov\u011b l\u00e9ka\u0159i ka\u017ed\u00fd den diagnostikuj\u00ed t\u00e9m\u011b\u0159 900 nov\u00fdch p\u0159\u00edpad\u016f zhoubn\u00fdch n\u00e1dor\u016f mozku a centr\u00e1ln\u00ed nervov\u00e9 soustavy \u2013 mezi n\u011b pat\u0159\u00ed i gliomy, nej\u010dast\u011bj\u0161\u00ed prim\u00e1rn\u00ed zhoubn\u00e9 n\u00e1dory mozku dosp\u011bl\u00fdch. (<\/strong>1,2) <\/strong>V \u010cesku se pacient\u016fm s gliomem 2. stupn\u011b a s mutac\u00ed IDH1 nebo IDH2 po operaci otev\u00edr\u00e1 mo\u017enost nov\u00e9 c\u00edlen\u00e9 l\u00e9\u010dby. Tato l\u00e9\u010dba m\u00e1 potenci\u00e1l ovlivnit r\u016fst n\u00e1doru a odd\u00e1lit tak v \u0159\u00e1du n\u011bkolika let dobu, kdy pacient bude pot\u0159ebovat dal\u0161\u00ed operaci, oza\u0159ov\u00e1n\u00ed nebo chemoterapii. Stejn\u011b tak m\u016f\u017ee sn\u00ed\u017eit u pacient\u016f v\u00fdskyt epileptick\u00fdch z\u00e1chvat\u016f. <\/strong>(4,5)<\/strong><\/p>\n\n\n\n

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\"Nov\u00e1<\/figure><\/div>\n\n\n
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L\u00e9\u010dba je u\u017e dostupn\u00e1 i v \u010cesk\u00e9 republice<\/h2>\n\n\n\n
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Nov\u00e1 c\u00edlen\u00e1 l\u00e9\u010dba mozkov\u00fdch n\u00e1dor\u016f, tzv. gliom\u016f 2. stupn\u011b s mutac\u00ed IDH1 nebo IDH2, byla v Evropsk\u00e9 unii schv\u00e1lena v z\u00e1\u0159\u00ed 2025. V \u010cesk\u00e9 republice je od 1. \u00fanora 2026 dostupn\u00e1 na z\u00e1klad\u011b \u017e\u00e1dosti o mimo\u0159\u00e1dnou \u00fahradu podle \u00a7 16 z\u00e1kona o ve\u0159ejn\u00e9m zdravotn\u00edm poji\u0161t\u011bn\u00ed. Standardn\u00ed \u00fahrada zat\u00edm nen\u00ed stanovena a o \u017e\u00e1dosti rozhoduje zdravotn\u00ed poji\u0161\u0165ovna individu\u00e1ln\u011b. (7,8)<\/p>\n\n\n\n

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\"Nov\u00e1<\/figure><\/div>\n\n\n
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\u201eJsem velmi r\u00e1d, \u017ee se zdravotn\u00ed poji\u0161\u0165ovny stav\u00ed k t\u00e9to modern\u00ed c\u00edlen\u00e9 l\u00e9\u010db\u011b otev\u0159en\u011b a vn\u00edmaj\u00ed velkou medic\u00ednskou pot\u0159ebu u pacient\u016f s n\u00e1dory mozku. V\u0161echny \u017e\u00e1dosti o jej\u00ed \u00fahradu, kter\u00e9 jsme dosud podali u vybran\u00fdch pacient\u016f s n\u00e1dorem s mutac\u00ed IDH1 nebo IDH2, byly schv\u00e1leny. Pro n\u00e1s i pro pacienty je podstatn\u00e9, \u017ee m\u016f\u017eeme tuto mo\u017enost skute\u010dn\u011b vyu\u017e\u00edt,\u201c<\/em> uv\u00e1d\u00ed MUDr. Tom\u00e1\u0161 Nov\u00e1k<\/strong> z Onkologick\u00e9 kliniky 2. LF UK a Fakultn\u00ed nemocnice Motol a Homolka.<\/p>\n\n\n\n

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Nemoc zasahuje mlad\u00e9 lidi v aktivn\u00edm v\u011bku<\/h2>\n\n\n\n
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Gliom 2. stupn\u011b roste pomaleji ne\u017e agresivn\u011bj\u0161\u00ed n\u00e1dory mozku. P\u0159esto pror\u016fst\u00e1 do okoln\u00ed mozkov\u00e9 tk\u00e1n\u011b a m\u016f\u017ee postupovat do vy\u0161\u0161\u00edho stupn\u011b. \u010casto se objevuje u mlad\u00fdch lid\u00ed od 20 do 45 let. Nemoc tak zasahuje do nejaktivn\u011bj\u0161\u00ed \u010d\u00e1sti \u017eivota, a\u0165 u\u017e jde o obdob\u00ed pr\u00e1ce, zakl\u00e1d\u00e1n\u00ed rodiny \u010di p\u00e9\u010de o d\u011bti. Pr\u016fb\u011bh onemocn\u011bn\u00ed gliomem 2. stupn\u011b mohou nav\u00edc prov\u00e1zet dal\u0161\u00ed p\u0159idru\u017een\u00e9 obt\u00ed\u017ee, jako jsou epileptick\u00e9 z\u00e1chvaty, zm\u011bny kognitivn\u00edch funkc\u00ed a dlouhodob\u00e1 nejistota spojen\u00e1 s kontroln\u00edmi vy\u0161et\u0159en\u00edmi. (6)<\/p>\n\n\n\n

O vhodn\u00e9m postupu l\u00e9\u010dby rozhoduje p\u0159esn\u00e1 diagn\u00f3za v\u010detn\u011b molekul\u00e1rn\u00edho vy\u0161et\u0159en\u00ed n\u00e1doru. Modern\u00ed c\u00edlen\u00e1 l\u00e9\u010dba zasahuje do \u010dinnosti zm\u011bn\u011bn\u00fdch enzym\u016f IDH, kter\u00e9 se pod\u00edlej\u00ed na r\u016fstu n\u00e1dorov\u00fdch bun\u011bk. Nej\u010dast\u011bji se vol\u00ed u pacient\u016f s astrocytomem nebo oligodendrogliomem 2. stupn\u011b, kte\u0159\u00ed dosud podstoupili pouze chirurgick\u00fd z\u00e1krok a bezprost\u0159edn\u011b nepot\u0159ebuj\u00ed oza\u0159ov\u00e1n\u00ed ani chemoterapii. (3)<\/p>\n\n\n\n

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\"Nov\u00e1<\/figure><\/div>\n\n\n
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\u201eDosud jsme nem\u011bli p\u0159im\u011b\u0159enou l\u00e9\u010debnou mo\u017enost, kter\u00e1 by byla schopna aktivn\u011b ovliv\u0148ovat pr\u016fb\u011bh t\u011bchto onemocn\u011bn\u00ed. U vhodn\u011b vybran\u00fdch pacient\u016f m\u00e1 tato l\u00e9\u010dba potenci\u00e1l prodlou\u017eit dobu do progrese onemocn\u011bn\u00ed a nab\u00eddnout mo\u017enost odd\u00e1lit nutnost dal\u0161\u00ed intervence, a\u0165 u\u017e chirurgick\u00e9, n\u00e1sledovan\u00e9 radioterapi\u00ed a chemoterapi\u00ed, \u010di pouze nechirurgick\u00e9 \u2013 to znamen\u00e1 zah\u00e1jen\u00ed radioterapie a chemoterapie,<\/em>\u201c \u0159\u00edk\u00e1 MUDr. Tom\u00e1\u0161 Nov\u00e1k<\/strong> a dod\u00e1v\u00e1: \u201eL\u00e9\u010dba v\u0161ak vy\u017eaduje pravideln\u00e9 l\u00e9ka\u0159sk\u00e9 kontroly, mimo jin\u00e9 kv\u016fli monitoraci s\u00e9rov\u00fdch hladin jatern\u00edch enzym\u016f.<\/em>\u201c<\/p>\n\n\n\n

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Pacienti cht\u011bj\u00ed z\u016fstat aktivn\u00ed a b\u00fdt se svou rodinou<\/h2>\n\n\n\n
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Kvalitativn\u00ed v\u00fdzkum Hlasu onkologick\u00fdch pacient\u016f (HOP) p\u0159ibli\u017euje dopady nemoci na ka\u017edodenn\u00ed \u017eivot. Pacienti s r\u016fzn\u00fdmi n\u00e1dory mozku a jejich bl\u00edzc\u00ed popisovali jako velmi slo\u017eit\u00e9 doj\u00ed\u017ed\u011bn\u00ed na l\u00e9\u010dbu, \u010dek\u00e1n\u00ed na v\u00fdsledky, nejistotu p\u0159ed kontrolami, pot\u00ed\u017ee s n\u00e1vratem do pr\u00e1ce i finan\u010dn\u00ed a rodinnou z\u00e1t\u011b\u017e. Za d\u016fle\u017eitou oporu pova\u017eovali bl\u00edzk\u00e9 a mo\u017enost z\u016fstat aktivn\u00ed a c\u00edtit se u\u017eite\u010dn\u00ed. (9)<\/p>\n\n\n\n

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\"Nov\u00e1<\/figure><\/div>\n\n\n
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Sv\u00e9 zku\u0161enosti m\u00e1 i Krist\u00fdna. Siln\u00e9 bolesti hlavy, slabost a nevolnosti ji p\u0159ivedly na vy\u0161et\u0159en\u00ed. N\u00e1dor odhalila magnetick\u00e1 rezonance na konci srpna 2023 a 11. z\u00e1\u0159\u00ed t\u00e9ho\u017e roku n\u00e1sledovala operace. Po n\u00ed ale p\u0159i\u0161ly dal\u0161\u00ed komplikace. Diagn\u00f3za Krist\u00fdny je dif\u00fazn\u00ed astrocytom Grade 2, IDH 1 pozitivn\u00ed. \u201eV\u011b\u0159ila jsem, \u017ee operac\u00ed moje cesta skon\u010d\u00ed. Pozd\u011bji, po t\u011bhotenstv\u00ed, se ale uk\u00e1zalo, \u017ee pot\u0159ebuji dal\u0161\u00ed l\u00e9\u010dbu. Nav\u00edc jsem p\u0159i\u0161la o sv\u00e9 dlouh\u00e9 vlasy,\u201c<\/em> popisuje Krist\u00fdna<\/strong>. Novou c\u00edlenou l\u00e9\u010dbu u\u017e\u00edv\u00e1 od 18. z\u00e1\u0159\u00ed tohoto roku.<\/p>\n\n\n\n

V\u00fdzkum HOP potvrzuje tak\u00e9 to, \u017ee pacienti pot\u0159ebuj\u00ed velkou psychologickou podporu, srozumiteln\u00e9 informace a pomoc s b\u011b\u017en\u00fdmi denn\u00edmi \u00fakoly. Bl\u00edzc\u00ed \u010dasto zaji\u0161\u0165uj\u00ed doprovod na vy\u0161et\u0159en\u00ed a p\u0159eb\u00edraj\u00ed p\u00e9\u010di o dom\u00e1cnost. (9)<\/p>\n\n\n\n

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\"Nov\u00e1<\/figure><\/div>\n\n\n
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A pr\u00e1v\u011b rodina je oporou tak\u00e9 pro Krist\u00fdnu, kter\u00e1 dnes vychov\u00e1v\u00e1 p\u016flro\u010dn\u00edho syna. \u201eM\u016fj syn i man\u017eel jsou pro m\u011b nejv\u011bt\u0161\u00ed motivac\u00ed zvl\u00e1dnout celou l\u00e9\u010dbu. Man\u017eel mi nav\u00edc dod\u00e1val sebev\u011bdom\u00ed i ve chv\u00edl\u00edch, kdy jsem se sama nec\u00edtila dob\u0159e. P\u0159\u00e1la bych si, aby m\u016fj p\u0159\u00edb\u011bh uk\u00e1zal, \u017ee a\u0165 si \u010dlov\u011bk proch\u00e1z\u00ed \u010d\u00edmkoliv, nemus\u00ed v tom b\u00fdt s\u00e1m,\u201c<\/em> uzav\u00edr\u00e1 Krist\u00fdna<\/strong>.<\/p>\n\n\n\n

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\"Nov\u00e1<\/figure><\/div>\n\n\n
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C\u00edlen\u00e1 l\u00e9\u010dba m\u016f\u017ee pacient\u016fm p\u0159in\u00e9st v\u00edce \u010dasu bez zhor\u0161en\u00ed nemoci<\/h2>\n\n\n\n
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Hlavn\u00edm klinick\u00fdm p\u0159\u00ednosem nov\u00e9 c\u00edlen\u00e9 l\u00e9\u010dby je jej\u00ed potenci\u00e1l stabilizovat proces r\u016fstu n\u00e1doru v dlouh\u00e9m \u010dasov\u00e9m horizontu.<\/p>\n\n\n\n

V\u00edce ne\u017e osm pacient\u016f z deseti, kte\u0159\u00ed se \u00fa\u010dastnili klinick\u00e9 studie, nepot\u0159ebovalo dal\u0161\u00ed operaci, oza\u0159ov\u00e1n\u00ed ani chemoterapii a p\u0159ibli\u017en\u011b t\u0159i \u010dtvrtiny pacient\u016f nepot\u0159ebovaly dal\u0161\u00ed protin\u00e1dorovou l\u00e9\u010dbu. (2,4)<\/p>\n\n\n\n

L\u00e9\u010dba m\u00e1 vliv na sn\u00ed\u017een\u00ed epileptick\u00fdch z\u00e1chvat\u016f, co\u017e je \u010dast\u00fd projev onemocn\u011bn\u00ed u pacient\u016f s n\u00edzkostup\u0148ov\u00fdm gliomem.<\/p>\n\n\n\n

L\u00e9\u010dba vy\u017eaduje pravideln\u00e9 l\u00e9ka\u0159sk\u00e9 kontroly, mimo jin\u00e9 kv\u016fli monitoraci hladin jatern\u00edch enzym\u016f. (3)<\/p>\n\n\n\n

V klinick\u00e9 studii byla hodnocena i kvalita \u017eivota a bylo zji\u0161t\u011bno, \u017ee l\u00e9\u010dba nem\u00e1 nep\u0159\u00edzniv\u00fd vliv l\u00e9\u010dby na hodnocen\u00e9 kognitivn\u00ed funkce, nap\u0159\u00edklad pam\u011b\u0165 a soust\u0159ed\u011bn\u00ed, ani na kvalitu \u017eivota. (5) Pr\u00e1v\u011b zachov\u00e1n\u00ed dobr\u00e9 kvality \u017eivota pacient\u016f s n\u00e1dorem mozku je kl\u00ed\u010dov\u00e9 pro jejich fungov\u00e1n\u00ed v b\u011b\u017en\u00e9m \u017eivot\u011b a nov\u00e1 c\u00edlen\u00e1 l\u00e9\u010dba m\u00e1 potenci\u00e1l k tomuto pomoci.<\/p>\n\n\n\n

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\"Nov\u00e1<\/figure>\n\n\n\n
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Zdroj foto:<\/strong> Pixabay.com, Fakultn\u00ed nemocnice Motol a Homolka<\/p>\n\n\n\n

Reference:<\/strong><\/p>\n\n\n\n

    \n
  1. IARC. Global Cancer Observatory<\/a>: Cancer Today. GLOBOCAN 2024, verze 1.0. Brain, central nervous system fact sheet. 8. 7. 2026.<\/li>\n\n\n\n
  2. Mellinghoff IK et al. Vorasidenib in IDH1- or IDH2-Mutant Low-Grade Glioma. N Engl J Med. 2023;389:589\u2013601. doi:10.1056\/NEJMoa2304194<\/a>.<\/li>\n\n\n\n
  3. EMA. Voranigo (vorasidenib)<\/a>. Souhrn \u00fadaj\u016f o p\u0159\u00edpravku. Aktualizace 27. 8. 2026.<\/li>\n\n\n\n
  4. Cloughesy TF et al. INDIGO: Updated efficacy and safety. J Clin Oncol. 2026;44(suppl 16):abstr. 2010. doi:10.1200\/JCO.2026.44.16_suppl.2010<\/a>.<\/li>\n\n\n\n
  5. Cloughesy TF et al. INDIGO: secondary and exploratory endpoints. Lancet Oncol. 2025;26:1665\u20131675. doi:10.1016\/S1470-2045(25)00472-3<\/a>.<\/li>\n\n\n\n
  6. Miller JJ et al. IDH-mutant gliomas: SNO consensus review. Neuro Oncol. 2023;25:4\u201325. doi:10.1093\/neuonc\/noac207<\/a>.<\/li>\n\n\n\n
  7. EMA. Voranigo: EPAR \u2013 p\u0159ehled p\u0159\u00edpravku<\/a>. Registrace v EU 17. 9. 2025.<\/li>\n\n\n\n
  8. \u010cesk\u00e1 onkologick\u00e1 spole\u010dnost \u010cLS JEP. Modr\u00e1 kniha \u010cOS<\/a>. 2026.<\/li>\n<\/ol>\n\n\n\n

    Hlas onkologick\u00fdch pacient\u016f. Pot\u0159eby pacient\u016f s n\u00e1dorem mozku. Kvalitativn\u00ed v\u00fdzkum. \u0158\u00edjen 2025.<\/p>\n\n\n\n

    <\/div>\n","protected":false},"excerpt":{"rendered":"

    Celosv\u011btov\u011b l\u00e9ka\u0159i ka\u017ed\u00fd den diagnostikuj\u00ed t\u00e9m\u011b\u0159 900 nov\u00fdch p\u0159\u00edpad\u016f zhoubn\u00fdch n\u00e1dor\u016f mozku a centr\u00e1ln\u00ed nervov\u00e9 soustavy \u2013 mezi n\u011b pat\u0159\u00ed i gliomy, nej\u010dast\u011bj\u0161\u00ed prim\u00e1rn\u00ed zhoubn\u00e9 n\u00e1dory mozku dosp\u011bl\u00fdch. (1,2) V \u010cesku se pacient\u016fm s gliomem 2. stupn\u011b a s mutac\u00ed IDH1 nebo IDH2 po operaci otev\u00edr\u00e1 mo\u017enost nov\u00e9 c\u00edlen\u00e9 l\u00e9\u010dby. Tato l\u00e9\u010dba m\u00e1 potenci\u00e1l ovlivnit […]<\/p>\n","protected":false},"author":2,"featured_media":17524,"comment_status":"closed","ping_status":"closed","sticky":true,"template":"","format":"standard","meta":{"_mi_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"footnotes":""},"categories":[2,12,10],"tags":[396,399,398,397,51,144,98],"yoast_head":"\nNov\u00e1 l\u00e9\u010dba n\u00e1dor\u016f mozku m\u016f\u017ee zm\u011bnit progn\u00f3zu pacient\u016f. M\u00e1 potenci\u00e1l ovlivnit r\u016fst n\u00e1doru a odd\u00e1lit oza\u0159ov\u00e1n\u00ed i chemoterapii - WOMENHOUSE.cz<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/womenhouse.cz\/index.php\/2026\/11\/05\/nova-lecba-nadoru-mozku-muze-zmenit-prognozu-pacientu-ma-potencial-ovlivnit-rust-nadoru-a-oddalit-ozarovani-i-chemoterapii\/\" \/>\n<meta property=\"og:locale\" content=\"cs_CZ\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Nov\u00e1 l\u00e9\u010dba n\u00e1dor\u016f mozku m\u016f\u017ee zm\u011bnit progn\u00f3zu pacient\u016f. 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